Additional file 1 of Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts

Additional file 1: Table S1. Characteristic of PDOX models applied in the study. Table S2. List of antibodies used in the study. Table S3. Characteristics of cell clusters identified in DROP-seq data in mouse-derived TME. Table S4. Lists of differentially expressed genes between PDOXs and nude brain per each major cell type. Table S5. Characteristics of myeloid clusters identified in DROP-seq data. Table S6. Lists of differentially expressed genes between PDOXs, GL261 and their respective normal brain controls (Nu-NB, B6-NB) per each myeloid cell type. Table S7. List of gene signatures applied for scRNA-seq analysis. Table S8. Lists of differentially expressed genes between TMZ treated and control P3 PDOXs per each major cell type analyzed.

附加文件1：表S1。本研究所用PDOX模型（Patient-Derived Orthotopic Xenograft）的特征。表S2：本研究所用抗体列表。表S3：小鼠来源肿瘤微环境（Tumor Microenvironment, TME）中DROP-seq测序数据鉴定得到的细胞簇特征。表S4：针对各主要细胞类型，PDOX模型与裸鼠脑组织间的差异表达基因列表。表S5：DROP-seq测序数据中鉴定得到的髓系细胞簇特征。表S6：针对各髓系细胞类型，PDOX模型、GL261细胞与各自对应的正常脑组织对照（Nu-NB、B6-NB）间的差异表达基因列表。表S7：用于单细胞RNA测序（single-cell RNA sequencing, scRNA-seq）分析的基因特征列表。表S8：针对各已分析的主要细胞类型，替莫唑胺（Temozolomide, TMZ）处理组与对照组P3代PDOX模型间的差异表达基因列表。