The effect of Schisandra chinensis fruit extract (SCE) and Schisandrin B (SchB) on gene expression profile in TGF-β1-treated A7r5 rat aortic smooth muscle cell

Schisandra chinensis fruit extract (SCE) and its active ingredient Schisandrin B (SchB), which are effective in the treatment of vascular diseases, have been known to suppress transforming growth factor β1 (TGF-β1)-mediated Smad activation and myosin light chain (MLC) phosphorylation in vascular smooth muscle cells (VSMCs). However, it is still largely unknown about the pharmacologic effects and mechanisms of SCE and SchB on TGF-β1-induced intracellular signaling pathways in vascular smooth muscle cells (VSMCs).北五味子果实提取物（Schisandra chinensis fruit extract，SCE）及其活性成分五味子素B（Schisandrin B，SchB）在血管疾病治疗中具有确切疗效，现有研究已证实二者可抑制转化生长因子β1（transforming growth factor β1，TGF-β1）介导的血管平滑肌细胞（vascular smooth muscle cells，VSMCs）内的Smad活化与肌球蛋白轻链（myosin light chain，MLC）磷酸化过程。然而，目前对于SCE与SchB在TGF-β1诱导的血管平滑肌细胞内信号通路中的药理作用及具体分子机制，仍在很大程度上尚不明确。