The 2.3A Crystal Structure of Humanized Xenopus MDM2 with RO5545353
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The 2.3A Crystal Structure of Humanized Xenopus MDM2 with RO5545353 Descriptor: (2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide, E3 ubiquitin-protein ligase Mdm2, SULFATE ION Authors: Graves, B.J, Lukacs, C, Janson, C.A. Deposit date: 2013-07-28 Release date: 2014-07-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS MED.CHEM.LETT., 5, 2014
创建时间：
2013-07-28
