A novel bioluminescent herpes simplex 1 virus for in vivo monitoring of herpes simplex encephalitis
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA722311
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资源简介：
The development of new approaches to evaluate therapeutic strategies remains crucial to improve the outcome of herpes simplex encephalitis. We report on the development of a recombinant neurovirulent HSV-1 created by inserting two reporter genes coding for tdTomato fluorescent protein and Gaussia Luciferase (GLuc) enzyme, into the UL26-UL27 intergenic region of H25 clinical strain, via Cas9-gRNA-induced homology-directed recombination strategy
创建时间：
2021-04-15
