Additional lives saved versus deaths caused by loosening the age restrictions for rotavirus vaccines in WHO high and very high mortality group.

aAssumes point estimates for vaccine efficacy and intussusception risk and case-fatality estimates presented in Tables 1–3.bAssumes 20% relative increase in incidence and case fatality of intussusception compared to base scenario.cAssumes a doubling of RR of vaccine associated risk of intussusception among children receiving dose 1 beyond 15 wk of age.dPessimistic scenario assumes base scenario with: (1) 20% increase in background incidence and case fatality of intussusception compared to base scenario; (2) doubling of relative among children vaccinated with dose 1 beyond 15 wk of age; and (3) lower 95% confidence limit for vaccine efficacy.eOptimistic scenario assumes the upper confidence limit for vaccine efficacy in each setting.