Transcriptional profiling of zebrafish embryos after 96 h exposure to two subsequent concentrations of 4-methyl-3-deoxy-1,9,12-trihydroxyestra-1,3,5(10)7-tetraene-6,17-dione (MDTETD) and 12ß-trihydroxy-androsta-4,6-diene-3,17-dione (THADD)

The aim of this mRNA expression profiling experiment was to screen for ecotoxicogenomic fingerprints in zebrafish (Danio rerio) embryos as aquatic vertebrate non-target model exposed to sublethal concentrations of 4-methyl-3-deoxy-1,9,12-trihydroxyestra-1,3,5(10)7-tetraene-6,17-dione (MDTETD) and 12ß-trihydroxy-androsta-4,6-diene-3,17-dione (THADD). MDTETD and THADD both are degradation products of bile salts, which are steroid compounds from the digestive tracts of vertebrates, which enter the environment upon excretion, e.g. in manure.