Trancriptomic profiling of HCT116 colon cancer cells with or without PBRM1 knock-down by RNAi. Trancriptomic profiling of HCT116 colon cancer cells with or without PBRM1 knock-down by RNAi

To investigate the influence of PBRM1 on gene expression, we performed RNA-seq in HCT116 colon cancer cells with or without PBRM1 knock-down by RNAi (both shRNA and siRNA approaches were used), and identified differentially expressed genes in PBRM1 knock-down cells compared to control cells, which shows implications for PBRM1's biological function in colon cancer.