Convergence of oncogenic and hormone receptor pathways promotes pro-metastatic phenotypes.

ChEBI2013-03-31 更新2026-07-21 收录

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激素受体信号通路

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Convergence of oncogenic and hormone receptor pathways promotes pro-metastatic phenotypes.

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2013-03-31

NFIC1 suppresses migration and invasion of breast cancer cells through interferon-mediated Jak-STAT pathway

癌症转移机制

Jak-STAT信号通路

NFIC1, the longest isoform of NFIC, is essential for the regulation on spatiotemporal expressions of drug-metabolizing genes in liver. However, the role of NFIC1 in breast cancer is not clear. Here we

NIAID Data Ecosystem40

shRNAi profiling of human MDA-MB-231 cells expressing anti-p53 (shp53) short-hairpin RNAs treated with TFGbeta or control

癌症转移机制

转录组功能分析

TGFβ ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers. The molecular nature of this switch remains enigmatic.

NIAID Data Ecosystem30

Hypoxia-induced phase separation of ZHX2 drives 3D chromatin remodeling and cancer metastasis (ATAC-Seq). Hypoxia-induced phase separation of ZHX2 drives 3D chromatin remodeling and cancer metastasis (ATAC-Seq)

肿瘤表观遗传学

癌症转移机制

Hypoxia and dysregulation of three-dimensional (3D) chromatin architecture can both activate oncogenic transcriptomic profiles, thus contributing to tumor malignancy. But how hypoxia regulates 3D chro

NIAID Data Ecosystem00

Flag-RBM47 HITS-CLIP in brain metastatic derivatives of MDA-MB-231

RNA结合蛋白靶标

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Brain metastatic breast cancer cells were subjected to HITS-CLIP to identify the targets of the RNA binding protein RBM47 MDA231-BrM2a is characterized in PMID: 19421193; Related data published toget

NIAID Data Ecosystem40

Expression data from FSTL1 antibody treatment for 6 hours in CL1-0 lung cancer cell line.. Homo sapiens

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基因表达调控

We demonstrate that FSTL1 down-regulation shRNAs significantly increased cell migration and invasion in lung cancer cell lines in vitro, as well as in lung metastases in vivo We used microarrays to an

NIAID Data Ecosystem10

Convergence of oncogenic and hormone receptor pathways promotes pro-metastatic phenotypes.

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