Additional file 2 of Ancestry-specific predisposing germline variants in cancer

Additional file 2: Table S1. The demographic information of TCGA PanCanAtlas cohort with separate admixture populations. Table S2a. Ancestry-specific cancer-gene associations discovered from multivariate regression analyses. Table S2b. Ancestry-specific cancer-gene associations discovered from rare variant burden testing (Total Frequency Test- TFT). Table S3. Frequency of predisposing variants in TCGA PanCanAtlas and gnomAD-non-cancer subset across all ancestries. Table S4a. Ancestry-Specific Predisposing Variants as identified from Supp. Table.2. Table S4b. Summary of somatic second hit mutations in carriers of germline predisposing variants. Table S5a. Statistical analysis of gene expression in tumor samples of the variant carriers vs. non-carriers within each ancestry-cancer combination. Table S5b. Tumor RNAseq variant allele fractions and the somatic second hit events in germline predisposing variants with extreme expression within that cancer type. Table S6a. Post hoc power analyses to detect rare-variant associations in an aggregation test using SKAT. Table S6a. Down-sampling analysis for PCGP and SARC (cancers with at least 5 significantly associated germline genes in the European ancestry). Table S7. Prior studies that report ancestry-specific germline predisposition.