Metadate

We show that live attenuated Salmonella enterica Typhimurium mutants have antitumor potential in vivo against the aggressive melanoma model with no observable side effects. Intratumoral injection of attenuated S. enterica Typhimurium mediated the reduction of the tumor mass. Furthermore, we demonstrate that the tumor regression caused by our triple mutant is related to a shift to a pro-inflammatory response.