Mocs2

Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. Based on experiments with the human molybdopterin synthase ortholog, they are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]

真核生物的钼酶利用一种独特的钼辅因子（MoCo），该辅因子由蝶啶（称其为钼蝶啶）和催化活性金属钼组成。MoCo通过异源二聚酶钼蝶啶合酶由前体Z合成。钼蝶啶合酶的大亚基和小亚基均由该基因通过重叠的开放阅读框编码。最初认为这些蛋白质是由双顺反子转录本编码的。基于对人源钼蝶啶合酶同源物的实验，现在认为它们是由单顺反子转录本编码的。该位点还存在选择性剪接的转录本，这些转录本编码大亚基和小亚基。[提供者：RefSeq，2008年7月]