8-OxoG in GC-rich Sp1 binding sites enhances gene transcription during adipose tissue development in juvenile mice [RNA-Seq]

We observed that transcriptional activity and the number of active genes were significantly correlated with the distribution of 8-oxoG in gene promoter regions, as determined by liquid chromatography/mass spectrometry (LC/MS), and 8-oxoG and RNA sequencing RNA-sequencing of lung and adipose tissues isolated from two juvenile female C57BL/6 mice我们通过液相色谱-质谱联用（liquid chromatography/mass spectrometry, LC/MS）技术，以及对两只幼年雌性C57BL/6小鼠分离的肺组织和脂肪组织开展的8-氧代鸟嘌呤（8-oxoG）检测与RNA测序（RNA-sequencing）分析，观察到转录活性与活性基因数量与基因启动子区域的8-oxoG分布呈显著相关。