Supplementary materials: Impact analysis of expanding narrow-spectrum antibiotic use for children with ear, sinus and throat infections

These are peer-reviewed supplementary tables for the article 'Impact analysis of expanding narrow-spectrum antibiotic use for children with ear, sinus and throat infections' published in the Journal of Comparative Effectiveness Research.Table A-1. Complete Set of Parameters Used in the Model.Table A-2. Ranges Used for One-Way Sensitivity Analysis and Distributions Used for Probabilistic Sensitivity Analysis.Summary: Aim: Estimate the impacts treating acute respiratory tract infections (ARTIs) in children aged 6 months through 12 years with narrow-spectrum antibiotics. Materials & methods: Decision-tree model to estimate children’s health, healthcare utilization and costs, and caregiver’s time and costs for using narrow-spectrum antibiotics in eligible children with an ARTI, compared with current use of narrow- and broad-spectrum antibiotics. Results: Reduced adverse drug reactions by 35,750 (14%) cases) and 4750 (12%) fewer emergency department visits, 300 (12%) fewer hospitalizations, and 50,500 (10%) avoided outpatient visits. Annual healthcare costs fell by US$120 million (22%). Total societal costs declined by US$131 million (20%). Conclusion: National implementation of narrow-spectrum antibiotics to treat ARTIs in children improves patient outcomes and reduces caregiver burden and annual healthcare costs.

本数据集为发表于《比较有效性研究杂志》的论文《扩大窄谱抗生素在儿童耳、鼻、喉感染中的应用影响分析》的同行评审补充表格。表A-1：模型中使用的完整参数集。表A-2：单因素敏感性分析使用的范围和概率敏感性分析使用的分布。摘要：目的：评估使用窄谱抗生素治疗6个月至12岁儿童急性呼吸道感染（ARTI）的影响。研究方法与材料：采用决策树模型估算使用窄谱抗生素治疗符合ARTI条件的儿童的健康状况、医疗保健利用和成本，以及照护者的时间和成本，并与目前窄谱和广谱抗生素的使用情况进行比较。结果：减少了35,750（14%）例不良药物反应，以及4,750（12%）次急诊室就诊，300（12%）次住院，以及50,500（10%）次避免门诊就诊。年度医疗保健成本下降了1.2亿美元（22%）。总社会成本下降了1.31亿美元（20%）。结论：在全国范围内实施窄谱抗生素治疗儿童ARTI，可改善患者预后，减轻照护者负担，并降低年度医疗保健成本。