hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE208060
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资源简介：
Pal,D. et al. develop a synthetic human bone marrow milieu and identify that CDH2 mediates niche-dependent leukemia proliferation and treatment resistance. They show that CDH2 is targetable in vivo via ADH-1, which shows high efficacy and low toxicity in a very aggressive leukemia PDX model. Comparative gene expression profiling analysis of RNA-seq data for leukaemia samples before and after co-culture on iMSC and iANG cells
创建时间：
2022-09-15
