Guinea Pig Sub-placenta/Decidua RNA Sequencing Manuscript Supplemental Material

Placental insufficiency at mid-pregnancy, established through moderate maternal nutrient restriction, is characterized with fewer maternal spiral arteries lined by trophoblast, shallower trophoblast invasion and downregulation of genelists involved in the regulation of cell migration. Treatment of placenta insufficiency with a <i>hIGF1</i> nanoparticle results in marked changes to transporter activity and increases our mechanistic understanding of how therapies designed to improve fetal growth may impact the placenta.妊娠中期经适度母体营养限制诱导的胎盘功能不全，其特征为滋养层细胞衬覆的母体螺旋动脉数目减少、滋养层侵袭程度更浅，以及参与细胞迁移调控的基因列表表达下调。采用人类胰岛素样生长因子1（hIGF1）纳米颗粒治疗该胎盘功能不全，可显著改变胎盘转运活性，并增进我们对旨在改善胎儿生长的疗法如何作用于胎盘的机制性理解。