Aberrant basal cell clonal dynamics shape early lung carcinogenesis

We have used single-cell RNA sequencing (scRNA-seq) and low-input whole-genome sequencing (WGS) to investigate epithelial changes in the carcinogen-exposed airways and to track clonal trajectories. This dataset includes: Seurat object containing the processed scRNA-seq data for mouse tracheal cells from NTCU-treated and Control individuals. Seurat object containing data from epithelial subclustered cells isolated from mouse NTCU-treated and Control tracheal samples. Seurat object containing integrated data from human tracheal epithelial cells, sampled from both current-smoker and non-smoker individuals. The data spans multiple datasets and has been harmonised for downstream analysis. List of annotated substitutions, double base substitutions and indels detected across murine clones identified in WGS analyses.