Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study

Both genetic and non-genetic factors contribute to individual variation in the immune response to vaccination. Understanding how genetic background influences variation in both the magnitude and persistence of vaccine-induced immunity is vital for improving vaccine development and identifying possible causes of vaccine failure. Dogs provide a relevant biomedical model for investigating mammalian vaccine genetics; canine breed structure and long linkage disequilibrium simplify genetic studies in this species compared to humans. The objective of this study was to estimate the heritability of the antibody response to vaccination against viral and bacterial pathogens and to identify genes driving variation of the immune response to vaccination in Beagles. Sixty puppies were immunized following a standard vaccination schedule with an attenuated combination vaccine containing antigens for canine adenovirus type 2, canine distemper virus, canine parainfluenza virus, canine parvovirus, and four..., , , # Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study

This package of files accompanies the manuscript entitled: \"Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study\", Jeanna M. Blake, James Thompson, Harm HogenEsch, Kari J. Ekenstedt.

[https://doi.org/10.5061/dryad.g79cnp5z5](https://doi.org/10.5061/dryad.g79cnp5z5)

## Genotype data of 57 research Beagles run on the Affymetrix Axiom Canine HD 710K SNP array, with positions in CanFam3.1 reference. 

1\. Binary PLINK files containing genotype data of 57 research Beagles run on the Affymetrix Axiom Canine HD 710K SNP array with positions in CanFam3.1 reference.

* Immune_Researach_Beagles.fam - family ID, individual ID, sire ID, dam ID, sex (0 if unknown), phenotype value (-9 for missing data, phenotypes included in a separate file)
* Immune_Research_Beagles.bim - chromosome, variant identifier, position in centimorgans (...