The effect of FBS and cyclic mechanical stretch on serum starved mesenchymal stem cells

Conclusions: Our RNA-seq data revealed that both CMS and FBS activates quiescent MSCs through regulating similar genes and pathways. miR-337 is one of the main factors that regulate MSC activation by targeting PI3K-Akt pathway.结论：本研究的RNA测序（RNA-seq）数据显示，CMS与FBS可通过调控相似的基因与信号通路激活静息态间充质干细胞（MSCs）。miR-337是通过靶向PI3K-Akt信号通路调控间充质干细胞激活的核心因子之一。