The Role of SQSTM1 (P62) in Mitochondrial Function and Clearance in Human Cortical Neurons. The Role of SQSTM1 (P62) in Mitochondrial Function and Clearance in Human Cortical Neurons
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https://www.ncbi.nlm.nih.gov/bioproject/PRJEB39474
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We have assessed the importance of SQSTM1 in human induced pluripotent stem cell (iPSC)-derived cortical neurons with and without SQSTM1. By combining high-content imaging, RNA-Seq, and functional mitochondrial readouts, we showed that SQSTM1 depletion causes aberrations in mitochondrial gene expression and functionality in iPSC-derived neurons.
创建时间:
2021-01-21



