Comprehensive analysis of Long non-coding RNA expression in dorsal root ganglion reveals cell type specificity and dysregulation following nerve injury - Supplemetary Data

<b>Comprehensive analysis of Long non-coding RNA expression in dorsal root ganglion reveals cell type specificity and dysregulation following nerve injury - Supplemetary Data</b> <br> <br> S. Data 1: Novel LncRNAs in mouse and rat, in syntenically conserved regions between human, mouse and rat. S. Data 2: Novel LncRNAs in mouse DRG antisense of orthologous genes in mouse and rat. S. Data 3: Novel LncRNAs in rat DRG antisense of orthologous genes in mouse and rat. S. Data 4: Neuron sub-type specificity of ENSEMBL genes and novel LncRNAs. Neuron sub-type index is 1. MHN, 2. MHN (MI, IS), 3. C-LTMR, 4. MHN (IS), 5. MHN (IS), 6. MHN, 7. MHN (NS), 8. MR, 9. MHN, 10. MR. Average log2 expression holds the average expression in the neuron sub-type where the gene or LncRNAs was higher expressed. Expression SEM hold the standard error of the mean for the average expression estimator. S. Data 5: DE analysis results for IPSC-derived sensory neurons vs IPSC. Results are DESeq2 determined for the whole gene set of ENSEMBL genes and novel LncRNAs. Experimental design is ~ cell_line*condition. S. Data 6: Expression data for all antisense LncRNAs in IPSC-derived sensory neurons vs IPSC. S. Data 7: Expression data for all intergenic LncRNAs in IPSC-derived sensory neurons vs IPSC. S. Data 8: Expression data for all LncRNAs antisense of pain genes in IPSC-derived sensory neurons vs IPSC. S. Data 9: Expression data for all intergenic LncRNAs adjacent to pain genes in IPSC-derived sensory neurons vs IPSC. S. Data 10: Novel LncRNAs in human IPSC and mouse, in syntenically conserved regions between human, mouse and rat. S. Data 11: Novel LncRNAs in human IPSC antisense of orthologous genes in human and mouse. S. Data 12: DE analysis results for rat DRG SNT vs Sham. Results are DESeq2 determined for the whole gene set of ENSEMBL genes and novel LncRNAs. Experimental design is ~ condition. S. Data 13: Expression data for all antisense LncRNAs in rat DRG SNT vs Sham. S. Data 14: Expression data for all intergenic LncRNAs rat DRG SNT vs Sham. S. Data 15: DE analysis results for BALB/c mouse DRG SNI vs Sham. Results are DESeq2 determined for the whole gene set of ENSEMBL genes and novel LncRNAs. Experimental design is ~ sex + strain*condition. S. Data 16: DE analysis results for B10.D2 mouse DRG SNI vs Sham. Results are DESeq2 determined for the whole gene set of ENSEMBL genes and novel LncRNAs. Experimental design is ~ sex + strain*condition. S. Data 17: Expression data for all antisense LncRNAs in mouse DRG SNI vs Sham. S. Data 18: Expression data for all intergenic LncRNAs mouse DRG SNI vs Sham. <br>

<b>背根神经节（dorsal root ganglion, DRG）长链非编码RNA（Long non-coding RNA, lncRNA）表达全景分析揭示神经损伤后的细胞类型特异性与表达失调——补充数据集</b>

S. Data 1：人、小鼠与大鼠共线性保守区域内的小鼠及大鼠新型长链非编码RNA。

S. Data 2：小鼠背根神经节中，与小鼠和大鼠同源基因反义链对应的新型长链非编码RNA。

S. Data 3：大鼠背根神经节中，与小鼠和大鼠同源基因反义链对应的新型长链非编码RNA。

S. Data 4：ENSEMBL数据库基因及新型长链非编码RNA的神经元亚型特异性。神经元亚型索引如下：1. MHN，2. MHN（MI、IS），3. C类低阈值机械感受器神经元（C-low threshold mechanoreceptive neuron, C-LTMR），4. MHN（IS），5. MHN（IS），6. MHN，7. MHN（NS），8. MR，9. MHN，10. MR。平均log₂表达量指该基因或长链非编码RNA在对应神经元亚型中的高表达均值；表达均值标准误（standard error of the mean, SEM）为该平均表达量估计值的标准误。

S. Data 5：诱导多能干细胞（induced pluripotent stem cell, IPSC）源性感觉神经元与IPSC的差异表达分析结果。该结果基于DESeq2工具对ENSEMBL数据库全基因集及新型长链非编码RNA进行分析得到，实验设计为~细胞系*处理条件。

S. Data 6：IPSC源性感觉神经元与IPSC中所有反义链长链非编码RNA的表达数据。

S. Data 7：IPSC源性感觉神经元与IPSC中所有基因间区长链非编码RNA的表达数据。

S. Data 8：IPSC源性感觉神经元与IPSC中所有与疼痛相关基因反义链对应的长链非编码RNA的表达数据。

S. Data 9：IPSC源性感觉神经元与IPSC中所有位于疼痛相关基因邻近区域的基因间区长链非编码RNA的表达数据。

S. Data 10：人、小鼠与大鼠共线性保守区域内的人IPSC及小鼠新型长链非编码RNA。

S. Data 11：人IPSC中，与人类和小鼠同源基因反义链对应的新型长链非编码RNA。

S. Data 12：大鼠背根神经节坐骨神经横断模型（spared nerve transection, SNT）与假手术组的差异表达分析结果。该结果基于DESeq2工具对ENSEMBL数据库全基因集及新型长链非编码RNA进行分析得到，实验设计为~处理条件。

S. Data 13：大鼠背根神经节SNT模型与假手术组中所有反义链长链非编码RNA的表达数据。

S. Data 14：大鼠背根神经节SNT模型与假手术组中所有基因间区长链非编码RNA的表达数据。

S. Data 15：BALB/c小鼠背根神经节坐骨神经损伤模型（spared nerve injury, SNI）与假手术组的差异表达分析结果。该结果基于DESeq2工具对ENSEMBL数据库全基因集及新型长链非编码RNA进行分析得到，实验设计为~性别 + 品系*处理条件。

S. Data 16：B10.D2小鼠背根神经节SNI模型与假手术组的差异表达分析结果。该结果基于DESeq2工具对ENSEMBL数据库全基因集及新型长链非编码RNA进行分析得到，实验设计为~性别 + 品系*处理条件。

S. Data 17：小鼠背根神经节SNI模型与假手术组中所有反义链长链非编码RNA的表达数据。

S. Data 18：小鼠背根神经节SNI模型与假手术组中所有基因间区长链非编码RNA的表达数据。