Supporting data for “The role of CXC chemokine receptor 3 in modulating neuroimmune responses and functional outcomes after experimental intracerebral haemorrhage”

All data were generated in vivo using the experimental mice model of ICH with type IV collagenase injection into the right striatum. The cellular and temporal patterns of CXCR3 expression prior to and after ICH induction were examined by different techniques. Systemic CXCR3 deficiency and antagonism highlighted the importance of CXCR3 in modulating outcomes of ICH, namely motor functions and the severity of white matter injury. CXCR3 deficiency altered the response of NK cells to ICH in this model.

所有数据均通过实验小鼠脑出血（ICH）模型，采用IV型胶原酶注射至右侧纹状体体内生成。通过多种技术手段，对脑出血诱导前后CXCR3表达的细胞和时序模式进行了研究。系统性CXCR3缺乏及其拮抗剂的使用突显了CXCR3在调节脑出血结局中的重要性，包括运动功能及白质损伤的严重程度。CXCR3缺乏在本模型中改变了自然杀伤细胞对脑出血的反应。