Luminance
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README for Luminance dataset Contact person for additional information: Jerome Sanes Jerome_Sanes@Brown.edu ORCID: 0000-0001-6320-7752 or Michael Worden worden@Brown.edu ORCID: 0000-0002-7126-6178 ## OVERVIEW Project Name: LUMINANCE Data collected: 2018 Studies with experimental animals have revealed a mood-regulating neural pathway linking intrinsically photosensitive retinal ganglion cells (ipRGCs) and the prefrontal cortex (PFC), involved in the pathophysiology of mood disorders. Since humans also have light-intensity-encoding ipRGCs, we investigated whether a similar pathway exists in humans. Dataset contains structural and functional MRI data and associated stimulus timing files ## Methods ### Subjects Subjects 20 healthy female and male participants from the local Providence, RI community (age 20-30 years old; 24.3 ± 3.7 years, mean ± s.d.). Participants underwent five runs of six minutes each during a single scan session. Each run consisted of twelve 30-second epochs of constant light intensity divided into three consecutive groups of four. Each group of four epochs contained all four light intensities [average light-intensity (irradiance) across the 400-700 nm human visible spectrum 10.2, 12.1, 13.1, and 13.8 log photons cm-2 s-1] in pseudorandom order. These light intensities corresponded to the following quantum catches of melanopsin: 11.5, 13.6, 14.6, and 15.2 log photons cm-2 s-1. Participants wore Teflon goggles that diffused the light. The light stimulus, as reported by the participants, did not contain any patterned visual information and covered the entire field of view. ). To ensure alertness during the scan session, participants performed an auditory task in which they discriminated between two presented tones (1 and 2 kHz, 100 msec duration) and indicated the perceived tone by pressing the left button for the 1 kHz tone and the right button for the 2 kHz tone. We recorded the time of the button press and response accuracy, finding no difference in reaction time or accuracy across the different light intensities.
