Reciprocal regulation of phosphatidylcholine synthesis and H3K36 methylation programs metabolic adaptation

Our findings demonstrated how phospholipid metabolism enabled metabolic transformation through an epigenetic modification, illuminating an underappreciated metabolic intersection for environmental adaptation in eukaryotic cells.本研究结果阐明了磷脂代谢（phospholipid metabolism）如何通过表观遗传修饰（epigenetic modification）介导代谢转化，同时揭示了真核细胞（eukaryotic cells）中此前未被充分重视的、参与环境适应的代谢交叉节点。