Dynamic dysregulation of the epigenome upon deletion of Mecp2 in adult mice

Loss of function mutations in methyl Cpg binding protein 2 (MECP2) cause Rett syndrome. Loss of MeCP2 causes global transcriptional dysregulation, but it was unknown whether this transcriptional dysregulation was proximal to Mecp2 function. We deleted Mecp2 from adult mice and performed a time-series CUT&RUN experiment to identify if MeCP2 binding or histone post-translational modficiations (specifically histone acetylation and methylation) are altered immediately upon loss of MeCP2.