Transcriptome analysis of aflatoxin B1 (AFB1) induced hepatocellular carcinoma (HCC) and AFB1 resistant liver sample from rats

Applied de novo assembly, both protein coding and non-coding RNAs were profiled in AFB1 induced HCC and AFB1 resistant liver sample. Compared with normal liver, the perturbation on transcriptome was revealed in multiple aspects, implying the potential mechanism of toxic resistance.本研究采用从头组装（de novo assembly）技术，对黄曲霉毒素B1（AFB1）诱导的肝细胞癌（HCC）样本及AFB1耐药肝脏样本中的蛋白编码RNA与非编码RNA进行了转录组表达谱分析。相较于正常肝脏组织，本研究从多个维度揭示了转录组的扰动特征，暗示了毒素耐药性的潜在作用机制。