Autonomic Dysfunction Among Adult Survivors of Childhood Cancer in the St. Jude Lifetime Cohort Study

The dataset contains all variables of interest presented in the study. By downloading and using these data, you agree that you will cite the appropriate publication in any communications or publications arising directly or indirectly from these data; for utilization of data available prior to publication, you agree to respect the requested responsibilities of resource users under 2003 Fort Lauderdale principles; you agree that you will never attempt to identify any participant. 

When using downloaded data, please cite corresponding paper and this repository:

John D. Groarke MBBCh et al. (2024) Autonomic dysfunction among adult survivors of childhood cancer in the St. Jude Lifetime Cohort Study, JACC: CardioOncology. Available at: https://www.sciencedirect.com/science/article/pii/S2666087324002825 

Funding:

Support to St. Jude Children’s Research Hospital was provided by the National Cancer Institute grants U01 CA195547 (Drs Hudson and Ness) and R01 CA157838 (Dr Armstrong), the Cancer Center Support (CORE) grant P30 CA21765 (Dr C. Roberts), and the American Lebanese-Syrian Associated Charities (ALSAC). Dr Groarke has received research support from Amgen, Inc, was previously employed by Amgen, Inc; and is currently an employee of Pfizer. Dr Nohria has received research support from Bristol Myers Squibb; and consulting fees from AstraZeneca, Bantam Pharmaceuticals, Regeneron Pharmaceuticals, and Takeda Oncology. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Data dictionary:   

ID: Serial numberAbn_HR: Abnormal HRBMI: BMI categoryBMIadj: BMI adjustedEF: Left ventricular ejection fractionMVPA150: Moderate to Vigorous physical activityPackYear: Pack years of smokingStatin: Statin therapyStudypop: PopulationabpelGY: Abdominal/Pelvic radiation dose,Gyacearb: ACE/AR inhibitorsagedx: Age at diagnosisagegxt: Age at CPETaldo: Aldosterone antagonistsalkyn: Alylating agentamputation: Amputationanthradose: Anthracycline dose mg/m2apelvdose: Abdominal/pelvic doseapelvrt: Abdominal/pelvic RTasparyn: Aspariginaseavgee: E/e' ratiobadmtns: mtnstot 5+betablock: Beta blockersbleoyn: Bleomycinbpblunt: Blunted blood presssure responsebrainGY: Cranial radiation dose,Gybrainrt: Brain RTcalcium: Calcium channel blockerscarboyn: CarboplatinchestGY: Chest radiation dose,Gychestrt: Chest RTci: Chronotropic incompetencecisyn: Cisplatindia: Diabetes mellituselevateRHR: Elevated HRfev1: Forced expiratory volume in 1 second (FEV1) < 80% predictedhowmany: N of Markers of Autonomic Dysfunctionhtn: Hypertensionlate10: Lateral e’ <10 cm/seclip: Dyslipidemialoop: Loop diureticsmale: Malemarkers2: 2 or more markers of Autonomic Dysfunctionmtxyn: Methotrexatenephrectomy: Nephrectomynewdx: Diagnosis grouppfat: % fat massplean: % lean masspou80: Impaired cardiorespiratory fitnessquadz: Quadricep strength zscoreriskydrk: Risky drinkingsepe7: Septal e’ <7 cm/secsixmpyn: 6 Mercaptopurinesmk: Smoking statusstime: Time since diagnosisstrainroc: GLS >=1.5thiaz: Thiazide diureticsthoracotomy: Thoractomyvi34: Left atrial volume index >34 ml/m2vincyn: Vincristineweek_min_pa: Weekly minutes physcial activity