High-throughput mRNA sequencing-based DEGs: HNF4A mitigates sepsis-associated lung injury by upregulating NCOR2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype

Sepsis can trigger systemic inflammation and lead to detrimental effects on several organs, with particular emphasis on the lungs. In sepsis-associated lung injury, macrophages assume a pivotal role, as their overactivation could facilitate the secretion of inflammatory factors and the imbalance of polarization. Hepatocyte nuclear factor 4 alpha (HNF4A) has been reported its potential involvement in the regulation of inflammatory response and macrophage polarization. This study discusses the role and mechanism of HNF4A in sepsis-induced lung damage. HNF4A exhibits a decrease in expression by analyzing the differentially expressed genes in the lungs of septic mice from the Gene Expression Omnibus dataset GSE15379. Then, we established a mouse sepsis model through a cecal ligation and puncture method, and observed that the expression of HNF4A was reduced in both lung tissues and alveolar macrophages. To e..., , , # High-throughput mRNA sequencing-based DEGs: HNF4A mitigates sepsis-associated lung injury by upregulating NCOR2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype

**Introduction**
This dataset includes information on high-throughput mRNA sequencing-based DEGs in the article “HNF4A mitigates sepsis-associated lung injury by upregulating NCOR2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype”.

**File list**
IL-4 + Ad-HNF4A + Dex + Ad-shNCOA2_vs_shNCIL-4 + Ad-HNF4A + Dex + Ad-shNCOA2.Differentially_Expressed_Genes, in xlsx format.

**Author Information**
Name: Yu-Hang Yang
Institution: Shengjing Hospital of China Medical University, Shenyang, China
Co-investigator 1
Name: Ri Wen
Institution: Shengjing Hospital of China Medical University, Shenyang, China
Co-investigator 2
Name: Xin-Mei Huang
Institution: Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
Co-investigator 3
Name: Tao Zhang
Institution: Shengjing Hospital of C...