Aida gene deficiency-related gut bacteria
收藏NIAID Data Ecosystem2026-05-10 收录
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资源简介：
The gut microbiota profoundly influences host physiology, yet how host genetics shape microbial function remains poorly understood. Using Aida-/- mice that are obese due to enhanced fat absorption, we show that AIDA deficiency enriches two Clostridia strains (XMU-68 and XMU-209). Paradoxically, monocolonizing wild-type mice with either strain ameliorates diet-induced obesity. Thus, strain expansion constitutes a compensatory adaptation that establishes a host-microbiota axis regulating systemic energy homeostasis.
创建时间：
2025-09-15
