Effect of oral administration of biliverdin on the liver transcriptome of aged Brandt's vole.

Biliverdin solution and saline was administrated by gavage once every day for 6 weeks. Specifically, thirty-two female voles (20-month-old) were randomly assigned to four groups: control group (F-BV-C voles, female voles administrated by saline, n = 8), low dose group (F-BV-L voles, female voles administrated by low dose biliverdin, n = 8), medium dose group (F-BV-M voles, female voles administrated by medium dose biliverdin n = 8), and high dose group (F-BV-H voles, female voles administrated by high dose biliverdin, n = 8). The setting and treatment of male voles (20-month-old) was the same as female voles, with control group (M-BV-C voles, male voles administrated by saline, n = 8), low dose group (M-BV-L voles, male voles administrated by low dose biliverdin, n = 8), medium dose group (M-BV-M voles, male voles administrated by medium dose biliverdin, n = 8), and high dose group (M-BV-H voles, male voles administrated by high dose biliverdin, n = 8).