Additional file 1: of Brain transcriptome analysis of a familial Alzheimer’s disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production

Genes differentially expressed between heterozygous mutant and wild type brains at 6 months. Lists the genes identified as differentially expressed between the brains of heterozygous psen1Q96_K97del mutant fish and the brains of their wild type siblings at an age of 6 months. Genes are ranked according to FDR-corrected p-value. Only genes with a FDR-corrected p-value less than 0.05 are shown. “FC” denotes fold change. “DE” denotes differential expression. For DE_Direction, “1” denotes increased expression in the mutant and “-1” denotes decreased expression in the mutant. (XLSX 39 kb)

本数据集收录6月龄杂合突变型与野生型脑组织的差异表达基因，具体为6月龄杂合psen1Q96_K97del突变型鱼类与其野生型同胞脑组织中鉴定得到的差异表达基因。基因依据经错误发现率（False Discovery Rate，FDR）校正后的p值进行排序，仅展示经FDR校正后p值小于0.05的基因。其中，“FC”指代折叠变化（fold change），“DE”指代差异表达（differential expression）。针对差异表达方向（DE_Direction）字段，“1”代表突变体中基因表达上调，“-1”代表突变体中基因表达下调。（XLSX 39 kb）