Effects of combined treatment of EGCG and environmental enrichment on postnatal mouse cortex regulome

The regulome constitutes a complex system of factors that control the molecular phenotype of the cell, which is influenced by the environment. Any disturbance can trigger a set of changes involving dysfunctional regulation of gene expression. The brain constantly integrates a multitude of motor, sensory and cognitive information. This process is particularly important in postnatal development when the brain must establish the molecular pattern needed to adapt to a changing environment. The aim of this study is to investigate how environmental factors influence the cerebral cortex regulome during postnatal development. In order to study the interaction between the regulome and the environment, we used the paradigm of environmental enrichment (EE) combined with the polyphenol Epigallocatechin Gallate (EGCG) during one month. Next Generation Sequencing (NGS) based techniques were employed to analyze the epigenome, chromatin accessibility, the transcriptome and the proteome