Multi-Ethnic Study of Atherosclerosis (BioLINCC)

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease. MESA researchers study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Thirty-eight percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent.

Data available for request include phenotypic data previously released on BioLINCC as well as raw images (E.g. Echocardiogram) and raw tracing data files (e.g. Electrocardiogram). These new data are intended to be made available to interested researchers via BioData Catalyst, will include participants irrespective of participation in genetics (i.e. the full MESA cohort), and may be merged with currently posted (to dbGaP) phenotype and molecular datasets (WGS, GWA, RNA Seq, Methylation, Metabolomics, and Proteomics).

多种族动脉粥样硬化研究（Multi-Ethnic Study of Atherosclerosis, MESA）是一项聚焦亚临床心血管疾病（即通过无创手段在出现临床症状与体征前检出的疾病）的特征，以及可预测疾病进展为显性临床心血管病或亚临床疾病自身进展的危险因素的研究。该研究团队针对6814名年龄介于45~84岁的无症状男女，构建了具有多样性的基于人群的样本队列。招募的参与者中，38%为白人，28%为非裔美国人，22%为西班牙裔，12%为亚裔，其中以华裔居多。

可申请获取的数据包括此前已在BioLINCC平台发布的表型数据，以及原始影像资料（例如超声心动图（Echocardiogram））与原始波形数据文件（例如心电图（Electrocardiogram））。上述新增数据将通过BioData Catalyst平台向有需求的研究人员开放，覆盖所有参与者（无需考虑是否参与遗传学研究，即涵盖完整的MESA队列），且可与目前已在dbGaP平台发布的表型及分子数据集（全基因组测序（Whole Genome Sequencing, WGS）、全基因组关联分析（Genome-Wide Association, GWA）、RNA测序（RNA Sequencing, RNA Seq）、甲基化组学（Methylation）、代谢组学（Metabolomics）及蛋白质组学（Proteomics））合并使用。