Three classes of discovered motifs.

A selection of three classes of discovered motifs. Each row shows DOM: SH3 domain for which the selected motif was discovered; MOTIF: motifs discovered in this study; LEN: motif length; pBAK: p-value scoring motif overrepresentation in positives relative to background (the proteome); pNEG: p-value for motif overrepresentation in positives compared to negatives; z-score: the z-score that corresponds to the least significant of pBAK and pNEG; ENR: binding energy; SOL: solvent accessibility; CON: sequence conservation; DIS: intrinsic disorder; OVR: overlap between discovered motifs and SH3 binding motifs of the SH3 domain. Symbols “+” and “-” mean respectively that, the average of the property (column) for regions in the positives covered by the discovered motif (row) is highly “similar” to or “different” from the average of the property (column) for known SH3 binding sites; the averages were compared with Student's t-test. We describe in material and methods how each property is obtained.