Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types [ATAC-seq]

To investigate the potential role of COVID-19 severity associated GWAS signals affecting the cis-regulatory architecure of human immune cell types. We used high-resolution chromatin conformation capture and accessibility to identify potential effector genes Overall design: We performed ATAC-seq, RNA-seq, and Promoter Focused Capture C on primary Monocytes, Naïve B and GCB cells