50-year-olds in Gothenburg - Study of men born in 1913 and their sons and men born in 1923, 1973 study

Starting in 1963 and with 10-year intervals, five population samples of men aged 50 and living in the city of Gothenborg, Sweden, were examined with respect to cardiovascular risk factors. In 1963, 973 men were invited. 855 of these took part in the study (88%). Clinical examinations were conducted at baseline and thereafter at 54 (1967), 60 (1973), 67 (1980), 75 (1988) and 80 years of age (1993). At every examination a number of questionnaires were filled in. For the 1973 study, 10% of all men born in 1923 were invited, providing a sample of 292, of which 226 (77%) participated. For the 1983 and 1993 studies, a random sample of half of all men in the city born in 1933 and 1943 were invited; 776 (76%) and 798 (55%), respectively, participated. In 2003 random third of all men (n =993) and women (n = 994) born in 1953 were invited. Participation rate was 60% among the men and 67% among the women. The study of men born in 1913 and their successors, men born in 1923, 1933, 1943 and 1953 provide opportunities to explore how living conditions have changed over four decades and what health effects these changes have had. From the start of the 60th century, the data have given opportunities to explore trends, as well as in cross-section as longitudinally. The studies have generated 12 thesis and more than 400 scientific papers. Purpose: To investigate coronary risk factors and the development of coronary disease in a group of Swedish urban men in the same age: 50 years. To the sampling in 2003 also women were invited.本研究自1963年起，每10年开展一次队列调查，针对瑞典哥德堡市50岁及以上男性人群的心血管疾病危险因素开展检测分析。1963年共邀请973名男性参与研究，最终855人完成全部研究流程，应答率为88%。研究于基线时开展临床检查，后续分别在受试者54岁（1967年）、60岁（1973年）、67岁（1980年）、75岁（1988年）及80岁（1993年）时进行随访临床检查，每次检查均完成多份调查问卷。 1973年的研究中，纳入1923年出生的全部男性人群的10%作为研究样本，共招募292人，其中226人参与研究，应答率为77%。1983年与1993年的研究分别纳入1933年、1943年出生的哥德堡市男性人群的50%作为随机抽样样本，分别有776人（应答率76%）与798人（应答率55%）参与研究。2003年，研究纳入1953年出生的全体人群中的三分之一作为随机样本，其中男性993人、女性994人，男性应答率为60%，女性应答率为67%。 本队列纳入了1913年出生男性及其后续出生队列（1923、1933、1943及1953年出生男性，2003年新增女性队列），为探究四十余年来生活环境的变化及其对健康产生的影响提供了研究基础。自20世纪60年代初启动以来，本数据集既可开展横断面分析，也可进行纵向追踪，以探索疾病与危险因素的变化趋势。截至目前，该系列研究已产出12篇学位论文及400余篇学术论文。 研究目的： 本研究旨在探究瑞典城市同龄50岁人群的冠心病危险因素及冠心病的发生发展过程。2003年的抽样研究同时纳入了女性人群。