Transcriptional correlates of high norepinephrine content in ovarian carcinomas

Genome-wide transcriptome profiling was conducted on 97 Stage I-IV ovarian carcinomas classified according to tissue norepinephrine content. To characterize the impact of norepinephrine on ovarian carcinoma biology, we conducted genome-wide transcriptome profiling of 97 clinical ovarian tumors. Tissue norepinephrine content was assessed by high performance liquid chromatogrphy (0=below median value of 1.05 pg/ml;1=above median). Covariates included age (years), body mass index (kg / m^2), tumor stage (1-4), and tumor grade (0=low;1=high).