Survival of Y. pestis-infected mice treated with GEN alone, CIN alone and a combination of CIN+GEN.

Groups of 19–20 mice were i.d. infected with 100 CFU of Y. pestis and were given antibiotics i.v., either alone or in combination and once or twice daily (depending on the antimicrobial). The first dose of drugs was given 44 h (experiment A) or 56 h (experiment B) after the Y. pestis inoculation.aTime point: 0, day of initiation of treatment; 1, one day after initiation of treatment; 5, the end of treatment-course; 10, euthanasia of survivors.