A talk given for CME at a radiation oncology conference. Target audience: dosimetrists and medical physicists, but likely available to most with an interest in science/maths.
It is generally accepted that radiotherapy must target clonogenic cells, i.e., those cells in a tumour that have self-renewing potential. Focussing on isolated clonogenic cells, however, may lead to a
Gene Expression Profiling of Mus spretus to study non-linearities in alternate splicing and molecular cancer barriers in mammary glands exposed to low-dose ionizing radiation.
Gene expression profiling was used to identify genes that display radiation-induced transcriptional change over tumor histopathology. Keywords: mouse squamous cell carcinoma, fibrosarcoma and mammary
