Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders

We report two bulk transcriptomic datasets of striatum from male and female mice carrying either the 16p11.2 hemideletion of 3 genes hemideletion knockout within this region. We performed bulk RNA sequencing gene expression analysis obtained from mouse striatum for two paradigms in both males and females: the full 16p11.2 hemideletion of 27 genes (16pdelhet vs. 16pdelhetWT) and the 3 genes knockout (3geneKOMut vs 3geneKOWT).本研究报道了两类来自雌雄小鼠纹状体（striatum）的批量转录组数据集（bulk transcriptomic datasets），受试小鼠分别携带16p11.2区域27个基因的完整半缺失，或该区域内3个基因的半缺失型敲除。我们针对雌雄小鼠的两种实验范式（paradigms），对小鼠纹状体样本开展了批量RNA测序（bulk RNA sequencing）及基因表达分析（gene expression analysis）：其一为包含27个基因的完整16p11.2片段半缺失模型（16pdelhet vs 16pdelhetWT），其二为3基因敲除模型（3geneKOMut vs 3geneKOWT）。