Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in a murine model. Mus musculus

TGFβ inhibition attenuates chronic cigarette smoke induced lung injury and rescues lung architecture. Overall design: AKR/J mice were exposed to Cigarette Smoke (CS) for a period of two months. Some animals received a treatment of Losartan (.6gr/L) orally while exposed (CS Los). These two groups are to be compared to animals that remained in Room Air (RA) and Room Air plus Losartan(0.6g/L) (RA Los) for any changes.