Impact of nisin G on the gut microbiota. Impact of the nisin G-producing S. salivarius DPC6487 on F. nucleatum in a model colonic environment

Fusobacterium nucleatum is a human pathogen associated with intestinal conditions including colorectal cancer (CRC). Screening for gut-derived strains that exhibit anti-F. nucleatum activity in vitro revealed Streptococcus salivarius DPC6487 as a strain of interest and producer of a novel nisin structural variant designated nisin G. Nisin G-producing S. salivarius DPC6487 demonstrated the ability to control F. nucleatum DSM15643 in an ex vivo model colonic environment, while exerting minimal impact on the surrounding microbiota. This submission contains shallow shotgun sequencing data reads, post QC and human host removal, from the ex vivo colonic modelling experiment.