ETV6-NCOA2 expression profile in T/M mixed-phenotype acute leukemia [ETV6-NCOA2 human]

Exparession profiling of ETV6-NCOA2 at different stages of disease dEmpty vectorelopment: CD34 cord blood cells transduced with ETV6-NCOA2-GFP or with empty vector-GFP, CD34 cord blood cells transduced with ETV6-NCOA2-NGFR or ETV6-NCOA2-NGFR + NOTCH1-L1601PdP-GFP and transplanted in NSGS mice, and ETV6-NCOA2 patient derived xenografts. Overall design: Expression profiling of ETV6-NCOA2 in human: CD34 positive cord blood cells transduced with ETV6-NCOA2 or empty vector, cultured five days in-vitro (n=3), ETV6-NCOA2 (n=3) or ETV6-NCOA2+NOTCH1-L1601PdP (n=5) transduced in CD34 positive cord blood cells and transplanted in NSGS mice, or ETV6-NCOA2 patient-derived xenografts (n=4).