Cascade Annulation of 2‑Alkynylthioanisoles with Unsaturated α‑Bromocarbonyls Leading to Thio-Benzobicyclic Skeletons

A protocol of Cu-catalyzed annulation of phenylethynylsulfanes with unsaturated α-bromocarbonyls for the construction of thio-benzobicyclic skeletons is described. In this single reaction, three new bonds and two new rings can be established, highlighting the step-economics and high efficiency of this protocol.