A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8‑Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease

We
report herein the identification of the rhodium­(III) complex
[Rh­(phq)2(MOPIP)]+ (1) as a potent
and selective ATP-competitive neural precursor cell expressed, developmentally
down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure–activity
relationship analysis indicated that the overall organometallic design
of complex 1 was important for anti-inflammatory activity.
Complex 1 showed promising anti-inflammatory activity
in vivo for the potential treatment of inflammatory bowel disease.