Ultra-deep mutational analysis of ALK kinase in primary anaplastic large cell lymphoma
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https://www.ncbi.nlm.nih.gov/sra/ERP008904
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资源简介：
We analyzed ALK kinase mutational status in 36 paediatric ALK-positive ALCL specimens at diagnosis, to identify point mutations and gene aberrations that could impact on NPM-ALK expression, activity and sensitivity to crizotinib. Mutations at low levels were detected, including missense substitutions R291Q and R335Q and splicing INDEL mutations.
创建时间：
2018-02-21
