Diastereoselective α‑Fluorination of N-tert-Butanesulfinyl Imidates
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https://figshare.com/articles/dataset/Diastereoselective_Fluorination_of_i_N_i_-_i_tert_i_-Butanesulfinyl_Imidates/7315637
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资源简介：
A diastereoselective α-fluorination of N-tert-butanesulfinyl imidates was developed. Deprotonation of N-tert-butanesulfinyl imidates with lithium hexamethyldisilazide generates aza-enolates that can be intercepted, with excellent diastereocontrol, by the inexpensive electrophilic fluorinating agent NFSI. This protocol was applied to the preparation of synthetically useful trans-2-fluoro-cyclohexamine with high enantiomeric purity (99.5% ee).
创建时间：
2018-11-08
