Hauser–Heck: Efficient Synthesis of γ‑Aryl-β-ketoesters en Route to Substituted Naphthalenes
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https://figshare.com/articles/dataset/Hauser_Heck_Efficient_Synthesis_of_Aryl_ketoesters_en_Route_to_Substituted_Naphthalenes/2107039
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资源简介：
γ-Aryl-β-ketoesters
can be prepared in one step from aryl bromides and bis(trimethylsilyl)
enol ethers using catalytic amounts of Pd(dba)2/t-Bu3P and stoichiometric amounts of Bu3SnF. The wide range of γ-(hetero)aryl-β-ketoesters that
can be obtained illustrate the scope and limitations of this novel
Hauser–Heck combination. γ-Aryl-β-ketoesters with
a 1,3-dioxane acetal in the ortho position can easily
be transformed into the hydroxy naphthoate in very good yield. Aqueous
formic acid at 65 °C provides optimal conditions for this deprotective
aromatization.
创建时间：
2016-02-12
