PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06939999
收藏Protein Data Bank Japan2023-10-18 更新2026-03-21 收录
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https://pdbj.org/mine/summary/7mxn
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PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06939999 Descriptor: (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 Authors: McTigue, M, Deng, Y.L, Liu, W, Brooun, A. Deposit date: 2021-05-19 Release date: 2021-11-17 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.55 Å) Cite: SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
创建时间：
2021-05-19
