Rhodium-Catalyzed Enantioselective Vinylogous Addition of Enol Ethers to Vinyldiazoacetates
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https://figshare.com/articles/dataset/Rhodium_Catalyzed_Enantioselective_Vinylogous_Addition_of_Enol_Ethers_to_Vinyldiazoacetates/2471428
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资源简介：
A highly asymmetric vinylogous addition of acyclic silyl
enol ethers
to siloxyvinyldiazoacetate is described. The reaction features a diastereoselective
1,4-siloxy group migration event. Products are obtained in up to 97%
ee. When more sterically crowded silyl enol ethers are employed, an
enantioselective formal [3+2] cycloaddition becomes the dominant reaction
pathway. Control experiments reveal the (Z)-olefin
geometry to be critical for high levels of enantiocontrol.
创建时间：
2016-02-20
