miRNA profile of plasma samples from Plasmodium vivax malaria patients and healthy subjects

Severe thrombocytopenia can be a determinant factor in the morbidity of Plasmodium vivax (Pv), the most widespread human malaria. Although immune mechanisms may drive Pv-induced severe thrombocytopenia (PvST), the current data on the cytokine landscape in PvST is scarce, and often conflicting. The analysis of the bidirectional circuit of inflammatory mediators and miRNAs would lead to a better understanding of the mechanisms underlying PvST. Unique samples from 34 subjects, including Plasmodium vivax malaria patients (n=26) and healthy subjects (n=8) were included in the study.